Research

Workflows on Shared HPC

Project Ongoing

Software Development & Optimization — make_lastz_chains (opens in a new tab)

Third-largest contributor, by commits, to the Hiller Lab's pipeline for whole-genome alignment chains. Authored the nf-core DSL2 refactor merged upstream in May 2026, which rebuilt the pipeline as modular Nextflow workflows. Other merged changes added Nextflow job arrays and run reports, fixed alignment of genomes larger than 4 GB, and capped task retries. Also helps users debug runs in the issue tracker.

Conference Paper

Optimizing Nextflow-based Software on Shared HPC Resources: A Case Study with make_lastz_chains (opens in a new tab)

US Research Software Engineer Association (US-RSE)

Practical lessons from supporting the make_lastz_chains genome-alignment pipeline on ASU supercomputers, where Nextflow submits many small Slurm jobs that erode a user's Fairshare score and stretch queue waits. Covers scheduling tactics, Fairshare impact, and reliably capturing Slurm errors, aimed at researchers, RSEs, and HPC support teams.

HPC Benchmarking

Birds of a Feather

Operational Data Analytics: Agentic AI for HPC Facilities (opens in a new tab)

International Conference for High Performance Computing, Networking, Storage, and Analysis (SC26)

Birds of a Feather session on operational data analytics (ODA) for HPC facilities, centered on agentic AI and how it can put the telemetry and operational data that sites collect to work. Co-organized with the ODA planning committee.

Project

ASU Supercomputers (opens in a new tab)

ASU Research Computing

Benchmarking and testing tools for ASU's supercomputers. HPL runs on Sol's A100 GPUs back ASU's Top500 and Green500 rankings, with HPCG and HPL-MxP runs alongside. After each maintenance window, a ReFrame suite runs node-level and MPI checks across ASU's clusters, including the OSU Micro-Benchmarks, and flags the nodes that need fixing before the systems return to production.

Computational Biology

Project Ongoing

Protein Structure Prediction and Structure-Based Phylogenetic Analysis

Predicts protein structures and uses the predicted structures for phylogenetic analysis.

Project Ongoing

Cyberinfrastructure Facilitation — Accelerating Multiple Allele Effects (opens in a new tab)

CIREN, Arizona State University

Cyberinfrastructure facilitator on a CIREN project with Michael Lynch that simulates how early RNA-like organisms evolve under mutation, natural selection, and genetic drift. The work translates the original C++ research code into Python, accelerates large-population simulations with PyTorch on GPUs, and validates results against the original models.

Journal Article

Longitudinal dynamics of the nasopharyngeal microbiome in response to SARS-CoV-2 Omicron variant and HIV infection in Kenyan women and their children (opens in a new tab)

mSystems, American Society for Microbiology

Followed the nasopharyngeal microbiome of Kenyan mothers and their children before, during, and after SARS-CoV-2 Omicron infection in a longitudinal cohort that included women living with HIV. Genomic epidemiology showed mother and child pairs carried the same rapidly spreading Omicron strain, and the cohort design separates how infection and HIV exposure each shape the airway microbiome.

Journal Article

Baseline Sequencing Surveillance of Public Clinical Testing, Hospitals, and Community Wastewater Reveals Rapid Emergence of SARS-CoV-2 Omicron Variant of Concern in Arizona, USA (opens in a new tab)

mBio, American Society for Microbiology

Baseline genomic surveillance that tracked SARS-CoV-2 across public clinical testing, hospitals, and community wastewater in Arizona, capturing the rapid takeover by the Omicron variant of concern. Pairing the three sampling streams shows how quickly a new variant can rise to dominance in a community.

Poster

A Clinical Decision Support System Based on Prescription Drug Monitoring Programs for Patient Pain Management

5th Annual Mayo Clinic–ASU BMI/BMD Student Poster and Employer Networking Event

Poster proposing a Clinical Decision Support System (CDSS) built on Prescription Drug Monitoring Programs (PDMPs) to support patient pain management, developed during a research affiliation at Mayo Clinic.

Journal Article

Prion protein is required for tumor necrosis factor alpha (TNFα)-triggered nuclear factor kappa B (NF-κB) signaling and cytokine production (opens in a new tab)

Journal of Biological Chemistry

Showed that cellular prion protein is required for TNFα-triggered NF-κB signaling and cytokine production: deleting PRNP in melanoma and pancreatic cancer cell lines silenced the response, and reintroducing it restored signaling. Mechanistically, prion protein keeps RIP1 and TRAF2 ubiquitinated by restraining the deubiquitinase CYLD. Selected as a JBC Recommended Read (Oct 2017).

Poster & Slides

A DNA Criticality-Detector Circuit in E. coli for Automatic Medicine-Dosage Thresholds

International Genetically Engineered Machine (iGEM) 2015 Jamboree

Slides and poster presentation for Team WHU-China's synthetic-biology project — a DNA criticality-detector circuit in E. coli designed as an automatic medicine-dosage threshold for addressing human dental caries. Awarded a Silver Medal.

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